Extracorporeal Membrane Oxygenation in COVID-19 Treatment: a Systematic Literature Review

Abstract Introduction: The present study intends to systematically review the literature on the use of extracorporeal membrane oxygenation (ECMO) in patients with coronavirus disease 2019 (COVID-19). Methods: The research was carried out according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Studies were selected from PubMed/MEDLINE and LILACS databases between December 2019 and May 17 2020, using the descriptors "ECMO AND COVID-19", "Extracorporeal Membrane Oxygenation AND COVID-19", "ECLS AND COVID-19", and "Extracorporeal Life Support AND COVID-19". Exclusion criteria were government epidemiological bulletins, comments, literature reviews, and articles without full access to content. Results: Two hundred and thirty-three scientific productions were found, however only 18 did not met the exclusion criteria and could be included in this study, amouting to a total of 911 patients - 624 (68.5%) men, 261 (28.6%) women, and 26 (2.8%) without sex information. The mean age of the patients was 53.7 years. ECMO was necessary in 274 (30.1%) people (200 [73%] submitted to veno-venous ECMO, nine [3.3%] to veno-arterial ECMO, and seven [2.5%] moved between these two types or needed a more specific ECMO according to the disease prognosis). Five studies did not specify the type of ECMO used, amounting 57 (20.8%) patients. Five patients (1.8%) were discharged, 77 (28.1%) died, 125 (45.6%) remained hospitalized until publication time of their respective studies, and 67 patients (24.4%) had no outcome information. Conclusion: It is evident that more research, covering larger populations, must be carried out in order to clearly elucidate the role of ECMO in the treatment of COVID-19.

Elderly Mortality from Cerebrovascular Disease in Alagoas, 2000-2016: Spatial-Temporal Analysis

Abstract Background Cerebrovascular diseases (CVDs) are the second leading cause of death in Brazil. Objective This study aimed to describe the epidemiological profile and to analyze the spatiotemporal dynamics of mortality from cerebrovascular disease in the elderly in Alagoas from 2000-2016. Methods This is a multilevel ecological study of all deaths from CVD in individuals aged 60 years or older. Data were collected from the Mortality Information System. The variables were submitted to descriptive analysis, trend analysis by Joinpoint Regression method and spatial analysis with Global Moran's and local statistics; 95% confidence interval and significance of 5% were considered in the analysis. Results There were 21,440 deaths in the study period, 50.4% (n=10,797) male, 40.5% (n=8,670) aged ≥ 80 years, 44.5% (n=9,465) of "brown" race, 30.1% (n=6,448) married and 36.5% (n=7,828) with less than four years of schooling. Female and male mortality rates were 460.24/100,000 and 602.23 / 100,000, respectively. An annual decreasing trend of -1.4% (p<0.001) in overall and male mortality was observed from 2007 on. The highest mortality rates were concentrated in the eastern region of Alagoas (Moran's I =0.766288; p=0.01). Twenty-two municipalities were in quadrant Q1 of Moran's scattering diagram and considered priorities. Conclusion Death from CVD in Alagoas occurred equally in men and women in the study period, mostly in individuals of mixed race, married, and with low education attainment. The highest rates were observed in the eastern region of the state . The results highlight the need for public policies aimed at healthy aging in the state. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)

Novo século, velho problema: tendência da mortalidade infantil e seus componentes no Nordeste brasileiro / New century, old problems: infant mortality trend and its components in the northeast region of Brazil

Resumo Introdução A mortalidade infantil ainda representa um desafio para os países em desenvolvimento. Objetivo Analisar a tendência da mortalidade infantil e seus componentes nos estados do Nordeste brasileiro entre 2001 e 2015. Método Estudo ecológico envolvendo quatro indicadores de mortalidade infantil: geral, neonatal precoce, neonatal tardia e pós-neonatal. Foi aplicado o modelo de regressão por pontos de inflexão (joinpoint regression). A tendência foi classificada em crescente, decrescente ou estacionária. Calculou-se o Percentual de Variação Anual (APC, Annual Percent Change), considerando Intervalo de Confiança de 95%. Resultados Foi observada tendência decrescente da mortalidade infantil geral no Nordeste (-3,9%) e em todos os estados, sendo Pernambuco com maior redução (-5,2%). Na mortalidade neonatal precoce, somente o Maranhão apresentou tendência estacionária (-0,2%). Na mortalidade neonatal tardia, Maranhão, Piauí, Paraíba e Sergipe apresentaram padrão estacionário. A mortalidade pós-neonatal foi a que apresentou maior redução, tendo destaque Alagoas (-8,6%) e Pernambuco (-7,6%). No Nordeste, esse componente apresentou variação anual de -6,1%. A partir do final da primeira década, a mortalidade pós-neonatal apresentou padrão estacionário no Nordeste, destacando-se Maranhão, Ceará, Rio Grande do Norte e Sergipe. Conclusão Embora tenha sido verificada redução da mortalidade infantil no Nordeste do Brasil, o comportamento estacionário em alguns estados configura motivo de preocupação, tendo em vista que os valores ainda são muito elevados quando comparados aos de locais desenvolvidos.

Abstract Background Infant mortality still represents a challenge for developing countries. Objective To assess the infant mortality trend and its components in the Brazilian Northeast states between 2001 and 2015. Method Ecological study consisting of four indicators of infant mortality were analyzed as following: general, early neonatal, late neonatal and post-neonatal mortalities. A regression analysis was applied to fit the inflection point (joinpoint regression). The trends were classified as increasing, decreasing or stationary. The Annual Percent Change (APC) was calculated considering a 95% confidence interval. Results Decreasing trend of overall infant mortality in the Northeast region (-3.9%) could be measured; the state of Pernambuco showed the greatest reduction (-5.2%). Regarding the early neonatal mortality, only the state of Maranhão showed stationary trends (-0.2%). With respect to the late neonatal mortality, the states of Maranhão, Piauí, Paraíba and Sergipe showed stationary pattern. The post-neonatal mortality presented the greatest reduction, being highlighted the values of this significant reduction in the states of Alagoas (-8.6) and Pernambuco (-7.6). Considering the entire region, this component showed an APC of -6.1%. At the end of the first decade, post-neonatal mortality showed a stationary pattern over the Northeast region, with the highest values in the states of Maranhão, Ceará, Rio Grande do Norte and Sergipe. Conclusion Although it has been a reduction in infant mortality in Northeastern Brazil, the stationary pattern in some states produced reasons for concern, considering that rates are still very elevated when compared to developed areas.

Covid-19 em Pacientes Oncológicos: uma Revisão do Perfil Clínico-Epidemiológico / COVID-19 in Oncologic Patients: a Clinical-Epidemiological Profile Review / Covid-19 en Pacientes con Cáncer: una Revisión del Perfil Clínico-Epidemiológico

Introdução: Desde o início da pandemia de Covid-19, estudos apontam que pacientes oncológicos representam um dos principais grupos de risco. Objetivo: Sintetizar a literatura no que se refere ao perfil clínico-epidemiológico de pacientes oncológicos com Covid-19. Método: Revisão integrativa da literatura a partir da base PubMed, utilizando os descritores COVID-19, SARS-CoV-2, 2019-nCoV, n-CoV e coronavirus combinados com cancer, tumor e malignancy. Resultados: Dos 821 artigos encontrados, nove textos foram incluídos na análise qualitativa, totalizando 39 indivíduos, com predomínio do sexo masculino (74,4% homens): China (6 textos, 35 pacientes), Nigéria (1 texto, 1 paciente), França (1 texto, 2 pacientes) e Dinamarca (1 texto, 1 paciente). Os cânceres de pulmão (51,3%; n=20) e de mama (10,3%; n=4) foram os mais prevalentes. Em 87,2% (n=34), não foram relatadas informações sobre hábitos de vida. Os sintomas respiratórios (46,8%; n=18) e febre (43,6%; n=17) se destacaram. Seis pacientes foram a óbito (15,4%), quatro receberam alta por cura (10,2%), dois permaneceram internados até a publicação do estudo (5,2%) e sobre os demais (69,3%, n=27) o manuscrito não informava o desfecho. Conclusão: O cuidado adequado a esse grupo especial de pacientes quando infectados pelo novo coronavírus é fundamental em busca de melhores desfechos. Mais estudos ainda são necessários para uma melhor compreensão de como a Covid-19 se comporta em pacientes com câncer.

Introduction: Since the beginning of COVID-19 pandemic, studies indicate that oncologic patients represent one of the main risk groups. Objective: To synthesize the literature addressing clinical and epidemiological profile of oncologic patients with COVID-19. Method: A systematic review of the literature was carried out in the PubMed database, utilizing the descriptors COVID-19, SARS-CoV-2, 2019-nCoV, n-CoV and coronavirus combined with cancer, tumor and malignancy. Results: Of the 821 articles found, nine texts were included in the qualitative analysis, totaling 39 individuals, predominantly male (74.4% men): China (6 texts, 35 patients), Nigeria (1 text, 1 patient), France (1 text, 2 patients), Denmark (1 text, 1 patient). Lung (51.3%; n=20) and breast (10.3%; n=4) cancers were the most prevalent. In 87.2% (n=34), information about life habits were not reported. Respiratory symptoms (46.8%; n=18) and fever (43.6%; n=17) stood out. Six patients died (15.4%), four were discharged due to cure (10.2%), two remained hospitalized until the study was published (5.2%) and for the other patients (69.3%, n=27), the manuscript did not inform the outcome . Conclusion: Adequate care for this special group of patients when infected with the new coronavirus is essential in pursuing better outcomes. Further studies are still needed to better understand how COVID-19 behaves in cancer patients.

Introducción: Desde el comienzo de la pandemia de Covid-19, los estudios indican que los pacientes con cáncer representan uno de los principales grupos de riesgo. Objetivo: Sintetizar la literatura sobre el perfil clínico-epidemiológico de pacientes con cáncer además de Covid-19. Método: Revisión integral de la literatura utilizando la base de datos PubMed, con los descriptores COVID-19, SARS-CoV-2, 2019-nCoV, n-CoV y coronavirus combinados con cáncer, tumor y malignidad. Resultados: De los 821 artículos encontrados, se incluyeron nueve textos en el análisis cualitativo, totalizando 39 individuos, predominantemente hombres (74.4% hombres): China (6 textos, 35 pacientes), Nigeria (1 texto, 1 paciente), Francia (1 texto, 2 pacientes), Dinamarca (1 texto, 1 paciente). Los cánceres de pulmón (51,3%; n=20) y de mama (10,3%; n=4) fueron los más prevalentes. En 87,2% (n=34) del total, no se informó ninguna información acerca de hábitos de vida. Se destacaron los síntomas respiratorios (46,8%; n=18) y fiebre (43,6%; n=17). Seis pacientes fallecieron (15,4%), cuatro fueron dados de alta por cura (10,2%), dos permanecieron hospitalizados hasta que se publicó el estudio (5,2%) y en los otros (69,3%, n=27) el manuscrito no informó el resultado. Conclusión: La atención adecuada para este grupo especial de pacientes cuando se infectan con el nuevo coronavirus es esencial en la búsqueda de mejores resultados. Todavía se necesitan más estudios para comprender mejor cómo se comporta Covid-19 en pacientes con cáncer.